PSB-SB-1203 (Compound 25b) is a dual CB1/CB2 ligand that blocks CB1 but activates CB2 receptors (CB1 Ki 0.244 μM; CB2 Ki 0.210 μM, EC50 0.054 μM). PSB-SB-1203 is promising for research of obesity and cancers[1].
IC 50
CB1: 0.244 μM (Ki); CB2: 0.21 μM (Ki)
References
[1] Rempel V, et al. 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists. J Med Chem. 2012 Sep 27;55(18):7967-77. DOI:10.1021/jm3008213
