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Azido-PEG2-PFP ester is a PEG linker with azide and PFP ester moieties. The azide can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to produce triazole linkages. The PFP is an amine reactive, activated ester. PFP esters form stable amide bonds and are less likely to undergo hydrolysis compared to other amine reactive moieties. The hydrophilic PEG linker increases the water solubility of compounds in aqueous environments.

N3-PEG2-C2-PFP ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG2-C2-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Non-cleavable Linker