13838-08-9

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• Preparation

  21.2 g of D-(-)-threo-1-p-nitrophenyl-2-aminopropane-1,3-diol was mixed with 10 g of azide acetonitrile (BP 68℃/25 mm) in a mixture of 125 ml methanol and 125 ml water, and stirred for several days at 30-40℃. The mixture was filtered off from a small amount of insoluble alkali, and the solvent was distilled under vacuum. The residue was treated with a small amount of hydrochloric acid until it reached Congo red, and extracted with ethyl acetate. azidamfenicol was given by solvent evaporation and recrystallization at MP 107℃.

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