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Methyl 3-formyl-2-nitrobenzoate is a phase transfer catalyst used to synthesize chlorinated hydrocarbons from inorganic chloride. It is soluble in organic solvents and can synthesize hydrochloric acid, sodium chloride, and zinc chloride. Methyl 3-formyl-2-nitrobenzoate is also used as a catalyst for producing polychlorinated biphenyls. It is hydrolyzed by water to release methyl 3-hydroxy-2-nitrobenzoate.

Methyl 3-?Formyl-?2-?nitrobenzoate is a reagent used in the synthesis of PARP inhibitors. Intermediate of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.