Uses
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent and selective ligand that can be used to investigate the interactions between ligand and receptor of estrogen receptors (ERs) (1,2,3). cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is an ERα agonist and an ERβ antagonist.
Definition
ChEBI:(R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. It has a role as an estrogen receptor antagonist, an estrogen receptor agonist, a geroprotector and a neuroprotective agent. It is a carbotetracyclic compound and a polyphenol.
Biological Activity
Non-steroidal, selective estrogen receptor ligand; agonist at ER α receptor (K i = 9.0 nM) and antagonist at ER β receptor (K i = 3.6 nM).
