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JWH 398 is a synthetic cannabinoid (CB) that activates both CB₁ and CB₂ receptors (K_i values of 2.3 and 2.8 nM, respectively). It has been reported to be an adulterant of herbal products. JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.

[1] SEBASTIAN DRESEN. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds[J]. Journal of Mass Spectrometry, 2010, 45 10: 1186-1194. DOI: 10.1002/jms.1811