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JWH 122 is a synthetic cannabinoid (CB) of the naphthoylindole class that is structurally related to JWH 018 and JWH 073. It displays high-affinities for both CB₁ (K_i = 0.69 nM) and CB₂ (K_i = 1.2 nM) receptors. JWH 122 N-(5-hydroxypentyl) metabolite is a metabolite of JWH 122 that is characterized by monohydroxylation of the N-alkyl chain. Currently, there are no reports of its biological activity.

JWH-122 5-Hydroxypentyl is a urinary metabolite of JWH-122.

[1] LUDGER ERNST . Identification and characterization of JWH-122 used as new ingredient in “Spice-like” herbal incenses[J]. Forensic science international, 2011, 208 1: Pages e31-e35. DOI: 10.1016/j.forsciint.2011.03.020
[2] MELANIE HUTTER. Metabolism of Nine Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of AM-694, AM-2201, JWH-007, JWH-019, JWH-203, JWH-307, MAM-2201, UR-144 and XLR-11 in Human Urine Using LC-MS/MS.[J]. Current pharmaceutical biotechnology, 2018, 19 2: 144-162. DOI: 10.2174/1389201019666180509163114