1371569-69-5

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoromethyl)pyrimidine acts as an allosteric modulator of the GLP-1 (glucagon-like peptide-1) receptor in preparation of orally therapeutic agents for the treatment of diabetes mellitus.

BETP is a positive allosteric modulator of the GLP-1 receptor th at potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cellsin the presence of the weak GLP-1 metaboliteGLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).''BetP is a trimeric Na+-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K+-concentration.

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