ChemicalBook CAS DataBase List 1370544-73-2

1370544-73-2

Name	AX-024 hcl
CAS	1370544-73-2
Molecular Formula	C21H22FNO2
Molecular Weight	339.4
MOL File	1370544-73-2.mol

Chemical Properties

Boiling point	452.0±45.0 °C(Predicted)
density	1.201±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:35.0(Max Conc. mg/mL);103.12(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);294.63(Max Conc. mM)
form	Solid
pka	9.26±0.20(Predicted)
color	Light yellow to yellow

Hazard Information

Description

AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation. AX-024 modulates cell signaling by targeting SH3 domains and has low-acute toxicity and high potency and selectivity in the inhibition of the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

Uses

AX-024, is >10,000-fold more potent than the AX-000 hit in terms of inhibition of TCR-triggered T cell proliferation. It is a cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.

in vitro

AX-024 reduces T cell proliferation upon weak T cell receptor (TCR) stimulation but neither significantly affects phosphorylation of Zap70 (ζ chain of T cell receptor–associated protein kinase 70) nor interacts directly with Nck1-SH3. AX-024 is likely not involved in modulating the Nck/TCR interaction but probably has other targets in T cells. An array of biophysical techniques did not detect a direct interaction between AX-024 and Nck-SH3.1 in vitro._x000D_ _x000D_ Reference: J Biol Chem. 2020 Jun 5;295(23):7849-7864. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278359/#B11

in vivo

AX-024-treated group presents less scales and reduces skin thickening compare to the vehicle group. AX-024 significantly reduces thickening of both skin layers, but more effectively of the dermis, which rather resembles that of mice treated with a control cream lacking imiquimod (IMQ). AX-024 significantly diminishes the number of airway inflammatory cells in both assays. Mice receiving AX-024 rapidly recovers from neurological impairment and weight loss, becoming symptom-free by day 30, unlike mice that receives the vehicle, in which ataxia and loss of the righting reflex persist^[1].

target

AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.

IC 50

IL-6; IL-10; IL-17A

storage

Store at -20°C

Supplier

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Beijing Solarbio Science & Tecnology Co., Ltd.

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Shanghai hongqu biomedical technology co. LTD

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ChemeGen

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Websitehttps://www.chemegen.com

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Telephone+86-027-59232304 15387063101

Websitehttps://www.yingnor.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

RD International Technology Co., Limited

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Websitehttps://www.ruidiresearch.com

Olix ( Hubei) Pharmaceutical Technology Co., Ltd

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Websitehttps://www.olix.cn

Shanghai Fengyong Biotechnology Co., Ltd.

Telephone021-10000000 13000000000

Websitehttps://www.abmole.cn

ATK CHEMICAL COMPANY LIMITED

Telephone+undefined-21-51877795

Websitehttp://www.atkchemical.com

HANGZHOU LEAP CHEM CO., LTD.

Telephone+86-571-87711850 +86-15355479329

Websitehttp://www.leapchem.com

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