136623-01-3

NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3].

ChEBI: NS-102 is a nitronaphthalene.

Competitive glutamate receptor antagonist with high selectivity for the low-affinity [3H] kainate binding site.

Store at -20°C

[1] Selva Baltan Tekk?k, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27(9):1540-52. DOI:10.1038/sj.jcbfm.9600455
[2] P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119(5):1047-1054. DOI:10.1093/bja/aex043
[3] Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7(3):e32483. DOI:10.1371/journal.pone.0032483