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5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine is a Pale-yellow to Yelow-brown Solid, it can undergo electrophilic and nucleophilic substitution reactions.

5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine is used in the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, a tyrosine kinase (TRK) inhibitor for treating cancer.

5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine has acute oral toxicity, it causes skin corrosion/irritation and serious eye damage/eye irritation.