1361504-77-9

DG-172 is an orally available inverse agonist of PPARβ/δ (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.

DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts.

PPARβ/δ: 27 nM (IC₅₀)

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