1361321-96-1

ACT-462206 is a potent and selective dual orexin receptor antagonist (DORA) that inhibits the stimulating effects of the orexin peptides at both the orexin 1 and 2 receptors. It decreases wakefulness and increases non-rapid eye movement (non-REM) and REM sleep while maintaining natural sleep architectures in some animal models while showing anxiolytic-like properties without affecting cognition and motor function in others.

ACT-462206 is a orally activebrain penetrantpotent and selective dual orexin1/2 receptor antagonist (DORA). ACT-462206 decreases wakefulnessdecreases sleep latencyand increases sleep efficacy in rats and dogs.''ACT-462206 is a proline sulphonamide with the potential to tre at insomnia. On absorptionits displays astheniablurred visionand fatigue as adverse events.

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