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4F-MPH is a novel psychoactive substance that is a fluorinated analogue of the prescription central nervous system stimulant methylphenidate (MPH), a dopamine and norepinephrine reuptake inhibitor used to treat attention deficit hyperactivity disorder. (±)-threo- and (±)-erythro- diastereomers (±) are present in 4F-MPH powders, but the bioactive compounds are (±)-threo-4-fluoromethylphenidate (4F-MPH). At present, studies have shown that 4F-MPH is toxic and has certain effects on the mind and heart of the human body^[1].

[1] PIETRO PAPA. Analytically Confirmed Intoxication by 4-Fluoromethylphenidate, an Analog of Methylphenidate.[J]. Journal of analytical toxicology, 2019, 43 5: e1-e7. DOI:10.1093/jat/bkz001.