1354030-52-6

Name	5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
CAS	1354030-52-6
Molecular Formula	C20H21Cl2N3OS
Molecular Weight	422.37
MOL File	1354030-52-6.mol

Synonyms

UNC9995 UNC-9995 UNC 9995 5-(3-(4-(2,3-Dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]t... 5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole Benzothiazole, 5-[3-[4-(2,3-dichlorophenyl)-1-piperazinyl]propoxy]-

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Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Description

UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%).

Uses

UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions[1].

in vivo

UNC9995 (2 mg/kg/day, i.p, 2 weeks) ameliorates depressive-like behavioral phenotype and improves the loss of astrocytes in the hippocampus in both Chronic social defeated stress (CSDS) model and Chronic unpredictable mild stress (CUMS) model in mouse^[1].

Animal Model:	Chronic unpredictable mild stress (CUMS) mouse model^[1]
Dosage:	2 mg/kg/d
Administration:	IP; 2 weeks
Result:	Improved depressive-like symptoms of CUMS mouse model in WT mice but not Arrb2^?/? mice.

IC 50

D₂ Receptor

References

[1] Liu Y, et al. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression. J Neuroinflammation. 2022 Oct 1;19(1):240. DOI:10.1186/s12974-022-02597-6

Supplier

Hefei TNJ Chemical Industry Co.,Ltd.

Telephone+86-0551-65418684 +8618949823763

Websitehttps://www.tnjchem.com

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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