13423-73-9

Hazard Information

Questions And Answer

• Synthesis

  

  In a 500ml reaction flask, add 133g (0.89mol) of p-hydroxybenzoic acid, 300g (5mol) of isopropanol, and 50g of solid acid, and stir until the solid is homogeneous. Place it in an ultrasonic reactor and install a reflux device. Set the reaction temperature to 40-60℃, the ultrasonic power to 500W, and react for 1-3 hours. The reaction solution gradually changes from white to yellow, and then to orange-red.

  The reaction conversion rate was monitored using HPLC (using the same method as in Example 1). The reaction was considered complete when the p-hydroxybenzoic acid content was less than 5%, at which point the reaction was stopped. The solid acid catalyst was filtered off and reused in the next reaction. The filtrate was allowed to crystallize at approximately 5–10°C for 6–10 hours. The crystals were filtered, dried at 50–60°C for 6 hours, and analyzed by HPLC. Impurities were found to be less than 0.1%, yielding 154 g of the intermediate 3,5-Diisopropyl-4-hydroxybenzoic acid, with a yield of 78%.;

Supplier

Related Products