ChemicalBook CAS DataBase List 13408-09-8

13408-09-8

Name	BETA-GLYCEROL PHOSPHATE DISODIUM SALT
CAS	13408-09-8
EINECS(EC#)	639-414-7
Molecular Formula	C3H7Na2O6P
MDL Number	MFCD00149083
Molecular Weight	216.037
MOL File	13408-09-8.mol

Chemical Properties

Melting point	>300°C
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	White powder
color	Whiteto Off-White
Water Solubility	Soluble in water.
Merck	14,8622
BRN	3744328
Stability:	Hygroscopic
InChI	InChI=1S/C3H9O6P.Na.H2O.H/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;1H2;
InChIKey	PEMUISUYOHQFQH-UHFFFAOYSA-L
SMILES	O(P(O)(O)=O)C(CO)CO.[NaH].O

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
WGK Germany	3
RTECS	UA0600000
F	10-21
TSCA	Yes
HS Code	29199000
Storage Class	11 - Combustible Solids

Hazard Information

Description

β-Glycerophosphate is a protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies. It promotes bone matrix mineralization when delivered to osteoblasts by providing a source of phosphate ions. β-Glycerophosphate (10 mM) accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.

Chemical Properties

Solid

Uses

β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.

General Description

A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor.

Biochem/physiol Actions

Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression

Purification Methods

Crystallise it from water. [Attwood et al. Biochem J 253 389 1988, Beilstein 1 IV 2766.]

References

[1]. chung ch, golub ee, forbes e, et al. mechanism of action of beta-glycerophosphate on bone cell mineralization. calcif tissue int. 1992 oct;51(4):305-11.
[2]. fujimoto h, mabuchi i. isolation of cleavage furrows from eggs of regular sea urchins and identification of furrow-specific proteins. j biochem. 1997 sep;122(3):518-24.
[3]. lecanda f, avioli lv, cheng sl. regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. j cell biochem. 1997 dec 1;67(3):386-96.
[4]. shioi a, nishizawa y, jono s, et al. beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. arterioscler thromb vasc biol. 1995 nov;15(11):2003-9.

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