133364-62-2

Name	DV 7028 hydrochloride
CAS	133364-62-2
Molecular Formula	C21H26ClFN4O3
MDL Number	MFCD00897569
Molecular Weight	436.91
MOL File	133364-62-2.mol

Synonyms

DV 7028 hydrochloride 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione hydrochloride

show less show more

Chemical Properties

storage temp.	Desiccate at RT
solubility	Soluble to 10 mM in water with gentle warming and to 10 mM in DMSO with gentle warming
form	Powder

Hazard Information

Description

Selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Exhibits no affinity for 5-HT1A, 5-HT1B or 5-HT1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models.

Uses

DV-7028 is a selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist[1].

in vivo

DV-7028 (0.1 mg/kg, intravenously) reduced the frequency of cyclic flow reductions by 77% in dog and improved the nadir of coronary blood flow velocity that indicated the severity of cyclic flow reductions ^[1].

IC 50

5-HT₂ Receptor

storage

Desiccate at RT

References

[1] Tanaka T, et al. Combined effect of the 5-HT2 receptor antagonist DV-7028 and aspirin or heparin on coronary cyclic flow reductions in dogs. Cardiovasc Res. 1993 Jul;27(7):1374-9. DOI:10.1093/cvr/27.7.1374

Supplier

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Shanghai Chengrui Biotechnology Co., Ltd

Telephone17316456674 15316859367

Websitehttps://www.chengrui.com

Related Products

156223-05-1 3681-99-0

163521-12-8 50-53-3

74050-98-9 50-67-9

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy