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L 158338 is an angiotensin receptor antagonist.

L 158338 is an angiotensin II receptor antagonist. L 158338 alleviates acidosis and increases coronary blood flow during the ischemic period and increases coronary blood flow during the reperfusion period. L 158338 can be used to study myocardial injury during ischemia and reperfusion[1].

[1] Werrmann J G, et al. Comparison of effects of angiotensin-converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in postischemic working rat heart as studied by [31P] nuclear magnetic resonance[J]. Journal of cardiovascular pharmacology, 1994, 24(4): 573-586. DOI:10.1097/00005344-199410000-00008