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• Preparation

  First, the nitrogen of 3-bromopyrazole was protected to form an N-dimethylsulfonyl derivative using dimethylsulfonyl chloride and triethylamine in dichloromethane; then, it was deprotonated with LDA/THF at -70 °C and carboxylated by passing CO₂ through it; finally, it was deprotected and esterified by hydrolysis with trifluoroacetic acid at room temperature for 1 h, and purified to obtain methyl 5-bromo-1H-pyrazole-3-carboxylate.;

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