1323883-62-0

T-1-PMPA is a potent EGFR inhibitor with apoptotic properties. T-1-PMPA effectively inhibits EGFRWT and EGFR790m, with IC50 values of 86 nM and 561.73 nM, respectively[1].

EGFR^WT: 86 nM (IC₅₀); EGFR^T790M: 561.73 nM (IC₅₀)

[1] Ibrahim H Eissa, et al. New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies. ACS Omega. 2024 Mar 27;9(14):15861-15881. DOI:10.1021/acsomega.3c08148