1322598-09-3

CATPB (cas# 1322598-09-3) is a useful research chemical.CATPB was used to prepare fluorescent tracer for the free fatty acid receptor 2 (FFA2/GPR43).

CATPB is an acetamidophenylbutanoate derivative with inverse agonist and antagonist activity against humanbut not mouse or ratFFA2 (GPR43). CATPB inhibits both constitutive and propionate (C3) -stimulated hFFA2 GTPγS incorporation (IC50 ~35 and 320 nMrespectively; [C3] = EC80~125 nM)as well as C3-induced hFFA2 G159E activity (IC50 ~400 nM). CATPB is shown to inhibit C3-induced intracellular ERK phosphorylation in hFFA2-expressing cells (IC50 ~3 μM against 10 mM C3).

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