131747-68-7

671776-91-3

131747-68-7

Under nitrogen protection, 5-(1,3-dioxolan-2-yl)pyridine-2-carbonitrile (478 mg, 2.71 mmol) was dissolved in THF (5.0 mL) followed by addition of 1 mol/L hydrochloric acid (5.0 mL). The reaction mixture was stirred at room temperature for 16 hours and then continued at 50 °C for 13 hours. Upon completion of the reaction, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate. The product was extracted with ethyl acetate and the organic phase was washed with saturated brine and dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give 5-formylpyridine-2-carbonitrile (364 mg, 100% yield).