ChemicalBook CAS DataBase List 13171-25-0

13171-25-0

Name	Trimetazidine dihydrochloride
CAS	13171-25-0
EINECS(EC#)	236-117-0
Molecular Formula	C14H24Cl2N2O3
MDL Number	MFCD00243086
Molecular Weight	339.26
MOL File	13171-25-0.mol

Chemical Properties

Appearance	Crystalline Solid
Melting point	231-235 °C(lit.)
storage temp.	Refrigerator
solubility	Freely soluble in water, sparingly soluble in alcohol.
form	neat
color	White to Off-White
Usage	Coronary vasodilator. Antianginal
Merck	14,9705
Stability:	Hygroscopic
InChI	InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H
InChIKey	XIRALXKCBGTYSC-UHFFFAOYSA-N
SMILES	C1(C=CC(OC)=C(OC)C=1OC)CN1CCNCC1.Cl.Cl
CAS DataBase Reference	13171-25-0(CAS DataBase Reference)

Safety Data

Hazard Codes	Xn,Xi
Risk Statements	R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
RTECS	TM2976100
HazardClass	IRRITANT
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Toxicity	LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey) less more

Hazard Information

Questions And Answer

Description
Trimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis. ;
References
Fragasso, G, et al. "A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. " Journal of the American College of Cardiology 48.5 (2006):992.
Tuunanen, H, et al. "Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy."Circulation 118.12(2008):1250.
Kantor, P. F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase."Circulation Research 86.5(2000):580.
Stanley, W. C., and M. Marzilli. "Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. "Fundamental & Clinical Pharmacology 17.2(2003):133–145.
Kantor, Paul F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase." Circulation research 86.5 (2000): 580-588. ;

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Animal Model:	Swiss albino male mice (24-35 g)^[4]
Dosage:	5 mg/kg, 10 mg/kg and 20 mg/kg; 10 mL/kg body weight
Administration:	Oral administration; 1 hour
Result:	In 10 mg/kg and 20 mg/kg doses significantly raised the seizure-threshold current in the ICES test.

13171-25-0

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