1315355-93-1

NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

MAP4K2: 21.7 nM (IC₅₀); TAK1: 149 nM (IC₅₀); LYN: 12.9 nM (IC₅₀); GSK: 56.4 nM (IC₅₀); ABL,ARG: 75.2 nM (IC₅₀); FER: 82.3 nM (IC₅₀); SRC: 113 nM (IC₅₀); Eph B2: 672 nM (IC₅₀); ZAK: 698 nM (IC₅₀); Eph A2: 773 nM (IC₅₀); Eph B4: 999 nM (IC₅₀); ZC1/HGK: 3250 nM (IC₅₀); RAF1: 7590 nM (IC₅₀)

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