Uses
Ipflufenoquin is used in the preparation of fungicidal compositions for the prevention and treatment of rice blast, and is suitable for the prevention and treatment of fungal diseases in rice, corn, fruits and vegetables.
Definition
ChEBI: Ipflufenoquin is a member of the class of quinolines that is quinoline substituted by a methyl group, 3-fluoro-2-(2-hydroxypropan-2-yl)phenoxy group, fluoro group and fluoro group at positions 2, 3, 7 and 8, respectively. It is a fungicide being developed by Nippon-Soda Co. Ltd (Japan) which has stable efficacy against a wide range of plant diseases, such as gray mold, scab and rice blast. It has a role as a fungicide. It is a member of quinolines, an organofluorine compound, an aromatic ether and a member of benzyl alcohols.
Production Methods
Ipflufenoquin is manufactured through a modular small-molecule route typical of modern quinoline-based fungicides: producers first build the substituted quinoline core from halogenated aniline and beta ketoester precursors via cyclisation, then introduce the key fluoroalkyl and ether substituents through controlled nucleophilic substitution or metal-catalysed coupling steps. The side-chain alcohol is installed late in the sequence to minimise degradation, followed by final oxidation or protection-deprotection steps to deliver the fully elaborated scaffold. After crude isolation, the active ingredient undergoes purification, crystallisation and quality control before being formulated into agricultural products.
Mechanism of action
Dihydroorotate dehydrogenase (DHODH) inhibitor
