ChemicalBook CAS DataBase List 13133-07-8

13133-07-8

Name	NISTOSE
CAS	13133-07-8
Molecular Formula	C24H42O21
MDL Number	MFCD00191672
Molecular Weight	666.58
MOL File	13133-07-8.mol

Synonyms

NISTOSE NYSTOSE 1)-α-D-Glup Nystose ,98% fungitetraose β-D-Fruf-(2-&gt 1,1-Kestotetraose NISTOSE USP/EP/BP 1)-β-D-Fruf-(2&lt 1)-β-D-Fruf-(2-&gt NistoseTrihydrate&gt Fungitetraose Nystose 1)-b-D-fructofuranosyl 1,1-Kestotetraose - 100mg Fructo-oligosaccharide DP4/GF3 1)-O-b-D-fructofuranosyl-(2&reg a-D-Glucopyranoside, O-b-D-fructofuranosyl-(2&reg β-d-fruf-(2->1)-β-d-fruf-(2->1)-β-d-fruf-(2<->1)-α-d-glup Nystose,β-D-Fruf-(2->1)-β-D-Fruf-(2->1)-β-D-Fruf-(2<-->1)-α-D-Glup 1-O-(1-O-β-D-Fructofuranosyl-β-D-fructofuranosyl)-β-D-fructofuranosyl α-D-glucopyranoside a-D-Glucopyranoside, O-b-D-fructofuranosyl-(21)-O-b-D-fructofuranosyl-(21)-b-D-fructofuranosyl α-D-Glucopyranoside, O-β-D-fructofuranosyl-(2→1)-O-β-D-fructofuranosyl-(2→1)-β-D-fructofuranosyl 2-O-(2-O-α-D-Glucopyranosyl-1-deoxy-β-D-fructofuranose-1-yl)-1-deoxy-β-D-fructofuranose-1-yl β-D-fructofuranoside (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-dimethylol-tetrahydrofuran-2-yl]oxymethyl]-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]oxymethyl]-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-6-methylol-tetrahydropyran-3,4,5-triol (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Chemical Properties

Melting point	130-133℃
Boiling point	1075.7±65.0 °C(Predicted)
density	1.84±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	10 ° (C=4, H2O)
storage temp.	2-8°C
solubility	H2O : 300 mg/mL (450.06 mM; Need ultrasonic and warming)
form	neat
pka	12.76±0.70(Predicted)
color	White to off-white
BRN	6171779
Major Application	food and beverages
InChIKey	FLDFNEBHEXLZRX-DLQNOBSRSA-N
SMILES	OC[C@H]1O[C@H](O[C@]4(CO[C@]3(CO[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]4O)[C@H](O)[C@@H](O)[C@@H]1O

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25 less more
WGK Germany	3
HS Code	29400090
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

White crystal

Uses

Fungitetraose is a part of the sugar mixture of Neosugar, sweetner.

Definition

ChEBI: Nystose is an oligosaccharide.

Synthesis

α-D-Glucopyranoside, O-1,3,4,6-tetra-O-acetyl-β-D-fructofuranosyl-(2→1)-O-3,4,6-tri-O-acetyl-β-D-fructofuranosyl-(2→1)-3,4,6-tri-O-acetyl-β-D-fructofuranosyl, 2,3,4,6-tetraacetate

25101-99-9

13133-07-8

The general procedure for the synthesis of the target compound from the compound (CAS: 25101-99-9) was as follows: 100 mg of Hex4perAc was dissolved in 5 mL of methanol (MeOH), followed by the addition of 18 mg (0.3 eq.) of sodium methanolate (CH3ONa). After stirring the reaction mixture for 2.5 h at room temperature, Dowex 50Wx2 [H+] resin was added to neutralize the reaction solution. The resin was removed by filtration and the solvent was removed by distillation under reduced pressure. The residue was dissolved in water (H2O) and desalted using a Bio-Gel P-2 gel (10 mL). Finally, a white solid product (57 mg) was obtained by freeze-drying.

in vivo

Nystose (100 mg/kg, po for 14 days) enhances the intestinal IgA secretion and modulates systemic immune responses in BALB/c mouse models^[2].
Nystose (40-160 mg/kg, po for 8 weeks) improves the bone density and bone microstructure in mouse models^[3].

Animal Model:	BALB/c mouse models^[2]
Dosage:	100 mg/kg
Administration:	po for 14 days
Result:	Inhibited the secretion of IL-2, IFN-γ, IL-12 and IL-4 by splenocytes.

Animal Model:	ICR mouse models^[3]
Dosage:	40-160 mg/kg
Administration:	po for 8 weeks
Result:	Improved the bone density and bone microstructure.

target

IFN-γ | IL Receptor

References

[1] Patent: CN103638162, 2016, B. Location in patent: Paragraph 0056
[2] Molecules, 2018, vol. 23, # 2,

Spectrum Detail

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Beijing HwrkChemical Technology Co., Ltd

Telephone89508211 18501085097

Websitehttp://www.hwrkchemical.com

Energy Chemical

Telephone 400-0056266

Websitehttp://www.energy-chemical.com

Adamas Reagent, Ltd.

Telephone4006009262 13023226327

Websitehttp://www.tansoole.com

ShangHai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttp://www.shyuanye.com

Chengdu Biopurify Phytochemicals Ltd.

Telephone+86-028-82633397 18982077548

Websitehttp://www.biopurify.cn

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Telephone025-66113011 13913916777

Websitehttp://www.aikonchem.com/

9ding chemical ( Shanghai) Limited

Telephone4009209199

Websitehttp://www.9dingchem.com

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-6206333 13167063860

Websitehttp://www.aladdin-e.com/

Shanghai Tauto Biotech Co., Ltd.

Telephone021-51320588

Websitehttp://www.tautobiotech.com/

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Cheng Du Pufeide Biotechnology Co., Ltd.

Telephone028-82610909 13388174823

Websitehttp://www.sc-victory.com

Chengdu Herbpurify Co.Ltd.

Telephone2355253622; 18981954830

Websitehttp://www.herbpurify.com

Shanghai BeiZhuo Biotech Co., Ltd.

Telephone021-61119791,13386096464

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16081/0_EN.htm

Shanghai JONLN Reagent Co., Ltd.

Telephone400-0066400 13621662912

Websitehttp://www.jonln.com

TianJin Alta Scientific Co., Ltd.

Telephone022-65378550-8551

Websitehttp://www.altascientific.cn

1of4

Related Products

Send Inquriy