ChemicalBook CAS DataBase List 1312815-93-2

1312815-93-2

Chemical Properties

density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 5 mg/ml
form	A crystalline solid
pka	15.05±0.10(Predicted)
color	White to off-white

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Animal Model:	Guinea pig with carrageenan stimulated air pouch inflammation model^[1]
Dosage:	10 mg/kg
Administration:	Administered orally
Result:	63% PGE2 inhibition.

Animal Model:	Sprague-Dawley rats^[1].
Dosage:	1.0 mg/kg (Pharmacokinetic Analysis)
Administration:	Administered i.v.
Result:	Clearance (CL), volume of distribution (Vd_ss), t_1/2, mean residence time (MRT) and bioavailability (F) is 12 mL/min/kg, 3.0 L/kg, 3.7 h, 4.42 h, 59%, respectively.