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• Synthesis

  

  Under inert gas protection, 2-methylphenylsulfonylhydrazine (1.1 mmol), benzonitrile (1.0 mmol), palladium catalyst (2 mol%), and biquinoline (bq, 3 mol%) were dispersed in an organic solvent (2 mL), and then H₂O (2 mmol) was added. The mixture was heated to 80 °C and reacted for 6 hours. The reaction solution was then extracted three times with Et₂O (5 mL). The organic phases were combined, and the solvent was evaporated under reduced pressure. The crude product was subjected to column chromatography (300-400 mesh) using a mixture of petroleum ether and ethyl acetate as the eluent to obtain the target product, 2-methylbenzophenone.

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