13096-31-6

15069-92-8

13096-31-6

The general procedure for the synthesis of 5-hydroxypiperidine-2-carboxylic acid from 5-hydroxypyridine-2-carboxylic acid was as follows: compound XII (350.00 g, 2.516 mmol, 1.0 eq.) was dissolved in a solvent mixture of water (5 L) and methanol (1 L), and Pd(OH)2/C catalyst (50.00 g) was added. The mixture was transferred to an autoclave, charged with hydrogen to a pressure of 3.5 MPa, and reacted at 65°C for 24 hours. The reaction progress was monitored by LC-MS and stopped after confirming the complete disappearance of the feedstock. The reaction mixture was filtered to remove the catalyst and the filtrate was concentrated several times with toluene to give a product in the form of a brown liquid (365.22 g, aqueous solution), which was used directly in the next step of the reaction in a yield of 100% based on theoretical values.