Description
JWH 073 is a mildly selective agonist of the central cannabinoid (CB
1) receptor derived from the aminoalkylindole WIN 55,212-
2. The K
i values for binding CB
1 and the peripheral cannabinoid (CB
2) receptor are 8.9 and 38 nM, respectively for a CB
1:CB
2 ratio of 0.23.
1 JWH 073 is one of several synthetic CBs which have been included in smoking mixtures. JWH 073 4-
hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-
related JWH 015 and JWH 018.
2,3
References
1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
3. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
