ChemicalBook CAS DataBase List 1303993-73-8

1303993-73-8

Name	(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
CAS	1303993-73-8
Molecular Formula	C8H7ClNNaO3
MDL Number	MFCD11100366
Molecular Weight	223.589
MOL File	1303993-73-8.mol

Chemical Properties

storage temp.	Store at RT
solubility	Soluble to 50 mM in water and to 50 mM in DMSO
form	Powder
color	Brown

Hazard Information

Uses

CHPG Sodium Salt (cas# 1303993-73-8) is a useful research chemical.Also, it is derived from 2-Chloro-5-hydroxybenzaldehyde (C368225), which is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine.

Biological Activity

CHPG sodium salt is a selective mGluR5 agonist and attenuates SO2-induced oxidative stress and inflammation in BV2 microglia via the TSG-6/NF-κB pathway. It prevents traumatic brain injury (TBI) in vitro and in vivo through the ERK and Akt pathways.

in vitro

CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO ₂ derivatives treatment.
It protects BV2 cells against SO ₂ -induced apoptosis.
It treatment alone increases the expression of TSG-6 in both mRNA and protein levels.

Cell Viability Assay

Cell Line:	BV2 microglial cells
Concentration:	10, 50, 100 and 500 μM
Incubation Time:	24 hours
Result:	Increased the cell viability.

< p class="cpd-mod-vv-tit "> Apoptosis Analysis

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Cell Line:	BV2 microglial cells
Concentration:	0.5 mM
Incubation Time:	30 mins
Result:	Protected BV2 cells against SO ₂ -induced apoptosis.

Western Blot Analysis

Cell Line:	BV2 microglial cells
Concentration:	0.5 mM
Incubation Time:	30 mins
Result:	Increased the expression of TSG-6 in both mRNA and protein levels.

Animal Model:	Adult Sprague-Dawley male rats weighing 280-320 g
Dosage:	250 nM < /td>
Administration:	Injection; for 7 days
Reduced significantly cerebral lesion volume.

1303993-73-8

Chemical Properties

Hazard Information

Uses

Biological Activity

in vitro

in vivo

target

storage

Supplier