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(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists[1].

[1] Muller A, et al. Comparative biological activities of the four synthetic (5,6)-dihete isomers. Prostaglandins. 1989 Dec;38(6):635-44. DOI:10.1016/0090-6980(89)90046-4