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Lipoxin A₄ (LXA₄) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA₄ is equipotent to leukotriene B₄ (LTB₄; Item Nos. 10007240 | 20110) in inducing superoxide generation in human neutrophils at 0.1 μM. LXA₄ is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.

LXA₄ MaxSpec^® standard is a quantitative grade standard of LXA₄ (Item No. 90410) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA₄ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion. Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.

Lipoxin A4 is a trihydroxy fatty acid produced through 15-HETE metabolism.

ChEBI: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-doubl bonds.

Caution! Product contains volatile liquid. Keep product cold at all times.

Lipoxin A4 (LXA4) is synthesized from arachidonic acid and is an endogenous lipoxygenase-derived eicosanoid mediator. It is a potent human protein kinase C activator. It inhibits cytotoxicity of natural killer cells. LXA4 regulates the immune system and inflammation. In the brain, it modulates neuronal signaling and slow wave sleep. LXA4 binds to cannabinoid receptors. LXA4 plays a key role in the maintenance of endometrium and reproductive function. Depletion of LXA4 contributes to the pathophysiology of cystic fibrosis (CF).

Store at -80°C, protect form light

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[2] C N SERHAN  B S  M Hamberg. Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1984, 81 17: 5335-5339. DOI: 10.1073/pnas.81.17.5335
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[4] J F MADDOX  C N S. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.[J]. Journal of Experimental Medicine, 1996, 183 1: 137-146. DOI: 10.1084/jem.183.1.137
[5] YILIN PANG . LC?MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI: 10.1016/j.freeradbiomed.2022.10.303
[6] FUYAO LIU. Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.[J]. Cell reports, 2020: 108049. DOI: 10.1016/j.celrep.2020.108049
[7] L KARRA. Lipoxin B4 promotes the resolution of allergic inflammation in the upper and lower airways of mice[J]. Mucosal Immunology, 2014, 8 4: 852-862. DOI: 10.1038/mi.2014.116