ChemicalBook CAS DataBase List 128700-97-0

128700-97-0

Name	(E)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPT-4-EN-3-ONE
CAS	128700-97-0
Molecular Formula	C21H24O5
MDL Number	MFCD06656136
Molecular Weight	356.41
MOL File	128700-97-0.mol

Chemical Properties

Boiling point	571.3±50.0 °C(Predicted)
density	1.183±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Ethanol (Slightly)
form	Oil
pka	10.01±0.20(Predicted)
color	Light Yellow to Yellow
InChI	InChI=1S/C21H24O5/c1-25-20-13-15(8-11-18(20)23)5-3-4-6-17(22)10-7-16-9-12-19(24)21(14-16)26-2/h4,6,8-9,11-14,23-24H,3,5,7,10H2,1-2H3/b6-4+
InChIKey	FWDXZNKYDTXGOT-GQCTYLIASA-N
SMILES	C(C1=CC=C(O)C(OC)=C1)CC(=O)/C=C/CCC1=CC=C(O)C(OC)=C1

Safety Data

Symbol(GHS)	GHS07,GHS08,GHS09
Signal word	Danger
Hazard statements	H302-H372-H410
Precautionary statements	P501-P273-P260-P264-P391-P308+P311

Hazard Information

Uses

Gingerenone A is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.

Definition

ChEBI: Gingerenone A is a diarylheptanoid.

Biological Activity

Gingerenone A is a potent anticancer agent isolated from Ginger (Zingiber officinale) th at exhibits minimal toxicity toward normal cells. Gingerenone A potently inhibits JAK2 (Janus Kinase 2) and S6K1 (p70 ribosomal S6 kinase). Gingerenone A significantly suppressed tumor growth in vivo. Alsoit exhibits promising senolytic properties. Gingerenone A selectively eliminate senescent cells in WI-38 human fibroblasts rendered senescent by exposure to ionizing radiation.

in vivo

Gingerenone A (10-50 mg/kg, orally, once a day, 15 weeks) reduces the increase in fat mass induced by a high-fat diet in mice by decreasing the size of fat cells, thereby inhibiting obesity and inflammation in adipose tissue^[2].
Gingerenone A (5-20 mg/kg, orally, once a day, 7 days) can alleviate ferroptosis in the SLI of DSS-induced colitis mice, and its protective effect is associated with the activation of the Nrf2-Gpx4 signaling pathway^[4].

Animal Model:	HFD mice^[2]
Dosage:	10, 50 mg/kg; daily; 15 weeks
Administration:	Oral
Result:	Reduced fat gain without significantly affecting caloric intake, reduced visceral fat mass, and made fat cells smaller.

Animal Model:	Mice induced by DSS^[6]
Dosage:	5, 20 mg/kg; daily; 7 days
Administration:	Oral
Result:	Alleviated DSS-induced liver pathological damage, liver parameters and cytokine levels, increased antioxidant enzyme activities, alleviated ferroptosis, upregulated GPX4 expression, and activated Nrf2.

Spectrum Detail

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