1279698-31-5

Name	QTX125
CAS	1279698-31-5
Molecular Formula	C23H19N3O5
MDL Number	MFCD34469284
Molecular Weight	417.41
MOL File	1279698-31-5.mol

Synonyms

QTX125 QTX125,QTX-125 1H-Pyrrole-2-carboxamide, 3-(3-furanyl)-N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-5-(4-hydroxyphenyl)-

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Chemical Properties

density	1.382±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	8.88±0.10(Predicted)

Hazard Information

Uses

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

in vivo

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice^[1].

Animal Model:	Nude mice bearing REC-1 or MINO cells^[1]
Dosage:	60 mg/kg
Administration:	Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result:	Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.

IC 50

HDAC6

storage

Store at -20°C

References

[1] Montserrat Pérez-Salvia, et al. In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Haematologica. 2018 Nov;103(11):e537-e540. DOI:10.3324/haematol.2018.189241

Supplier

Shanghai Chaolan Chemical Technology Center

Telephone021-QQ：65489617 15618227136

Websitehttp://www.atkchemical.com/

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Telephone86-571-88216897,88216896 13588875226

Websitehttp://www.hzclap.com/en/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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