1264754-13-3

E3L-4133, also known as E3 ligase Ligand 5, is an E3 ligase Ligand that can be used in PROTAC (proteolysis targeting chimera) technology to engage an E3 ubiquitin ligase. PROTAC is a two-headed molecule capable of removing specific unwanted proteins.

PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively[1].

PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist.

ERRα: 0.04 μM (IC₅₀); ERRγ: 2.8 μM (IC₅₀)

[1] Patch RJ, et al. Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents. J Med Chem. 2011 Feb 10;54(3):788-808. DOI:10.1021/jm101063h