126463-99-8
| Name | HUMAN MCP-1 |
| CAS | 126463-99-8 |
| MDL Number | MFCD00131621 |
Synonyms
JE
CCL2
MCAF
MCP-1
RHMCP-1
HUMAN MCAF
HUMAN CCL2
MCAF, HUMAN
HC11, HUMAN
HUMAN MCP-1
MCP-1, HUMAN
MCP1/CCL2, HUMAN
MCP-1/MCAF human
HUMAN MCP1 (CCL2)
HUMAN MCP-1 (MCAF)
JE (MCP-1) from mouse
JE/MCP-1 (CCL2) from mouse
Small inducible cytokine A2
MONOCYTE CHEMOTACTIC PROTEIN-1
RECOMBINANT HUMAN MCP-1 (MCAF)
MONOCYTE SECRETORY PROTEIN JE, HUMAN
HUMAN MONOCYTE CHEMOTACTIC PROTEIN 1
MONOCYTE CHEMOTACTIC PROTEIN-1, HUMAN
MONOCYTE CHEMOATTRACTANT PROTEIN-1, HUMAN
MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR
Monocyte Chemotactic Protein-1 from rat
Recombinant Mouse Ccl2/MCP-1 Protein, No Tag
Recombinant Mouse Ccl2/MCP-1 Protein, His Tag
HUMAN MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR
MACROPHAGE/MONOCYTE CHEMOTACTIC PROTEIN-1, HUMAN
MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR, HUMAN
HUMAN MCP1 (CCL2) CHEMICALLY SYNTHESIZED CHEMOKINE
MONOCYTE CHEMOTACTIC PROTEIN-1, HUMAN, RECOMBINANT
MONOCYTE CHEMOTACTIC PROTEIN-1, HUMAN, RECOMBINANT, E COLI
Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor
MCP-1 (huMan), MCAF (huMan), HC11 (huMan), SMall Inducible Cytokine A2 (huMan)
PYR-PRO-ASP-ALA-ILE-ASN-ALA-PRO-VAL-THR-CYS-CYS-TYR-ASN-PHE-THR-ASN-ARG-LYS-ILE-SER-VAL-GLN-ARG-LEU-ALA-SER-TYR-ARG-ARG-ILE-THR-SER-SER-LYS-CYS-PRO-LYS-GLU-ALA-VAL-ILE-PHE-LYS-THR-ILE-VAL-ALA-LYS-GLU-ILE-CYS-ALA-ASP-PRO-LYS-GLN-LYS-TRP-VAL-GLN-ASP-SER-MET-ASP-HIS-LEU-ASP-LYS-GLN-THR-GLN-THR-PRO-LYS-THR-OH
Hazard Information
Uses
Monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF) has been used:
- as a chemokine supplement in the alpha minimal essential medium for culturing neurons to test its effect on JmjC histone demethylase (Jmjd2a) mRNA
- as a component of Dulbecco′s Modified Eagle (DMEM) medium, as a positive chemoattractant control in HeLa cells for migration assay
- as a chemoattractant to induced macrophage chemotaxis
General Description
Monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF), also called the C-C motif chemokine ligand 2 (CCL2), is an inflammatory cytokine. The CCL2 gene is mapped to human chromosome 17q12. CCL2 is present in epithelial, endothelial, mesangial and microglial cells. Structurally, it dimerizes and has four regions of the ?-sheet. Recombinant human MCP-1 is a 8.6 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues. The MCP family cross-reacts across species.
Biochem/physiol Actions
Monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF) acts as a human immunodeficiency virus 1 (HIV-1) suppressor. The MCP-1 acts as a chemoattractant for T cells and natural killer (NK) cells. It also plays a key role in the migration and infiltration of macrophages. CCL2 shows under expression in high-grade ovarian serous carcinomas (HGOSCs) and is expressed less in epithelial ovarian cancer (EOC).
Supplier
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Zhejiang Jiekun Biotechnology Co., Ltd
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Taiyuan Bailihengkang Biotechnology Co., Ltd
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