Description
R 82150 is an antiviral drug and a member of the tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepin-2(1H)-thione family of compound.
Uses
R-82150 (TIBO-R 82150) is an HIV-1 reverse transcriptase inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses[1].
References
[1] Parker K A, et al. A four-step synthesis of TIBO R82150[J]. The Journal of Organic Chemistry, 1991, 56(15): 4600-4601.
