1254032-16-0

Name	Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-
CAS	1254032-16-0
Molecular Formula	C19H19N3O2
Molecular Weight	321.37
MOL File	1254032-16-0.mol

Synonyms

AR-13503 Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-

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Chemical Properties

Boiling point	649.2±55.0 °C(Predicted)
density	1.310±0.06 g/cm3(Predicted)
form	Solid
pka	12.89±0.43(Predicted)
color	White to off-white

Hazard Information

Uses

(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2].

in vivo

AR-13503 (1.25 mg/kg; i.p.; once daily for 5 days) in collaboration with Aflibercept (HY-108801), significantly decreases the development of aberrant neovascularization (NV)^[1].

Animal Model:	Oxygen-induced retinopathy (OIR) mice model (C57BL/6; 7-days-old)^[1]
Dosage:	1.25 mg/kg
Administration:	Intraperitoneal injection; once daily for 5 days
Result:	The combination group had a greater (~75%) reduction in NV than Aflibercept alone (~55%).

References

[1] Ding J, et al. ROCK/PKC inhibitor AR-13503 inhibits angiogenesis and protects the barrier function of retinal pigment epithelium[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 205-205.
[2] Carbajal K, et al. AR-13503 Enhances the efficacy of aflibercept in a mouse model of proliferative diabetic retinopathy[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 200-200.

Supplier

Hubei Xinyang Medical Technology Co., Ltd

Telephone 15347293736

Websitehttps://yongstandards.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

commedx

Telephone010-46598925 18519000250

Websitehttp://www.commedx.com

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Telephone025-58851090 17714375163

Websitehttps://www.aikonchem.com/

Hubei Rhema Reference Materials Technology Co., Ltd.

Telephone15787879035 15787875101

Websitehttps://www.chemicalbook.com/supplier/138770565/

ComMedX (Computational Medicine Beijing Co., Ltd.)

Telephone+86-18519000250 +86-18519000250

Websitehttp://www.commedx.com/en/

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