1246470-32-5

MK-4882 is a potent HCV NS5A inhibitor.

MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations.

[1] Discovery of potent macrocyclic HCV NS5A inhibitors DOI:10.1016/j.bmcl.2016.05.042
[2] Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity
[3] Discovery and development of hepatitis C virus NS5A replication complex inhibitors