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Zymosterol-d5 is the isotope labelled analog of Zymosterol, an sterol intermediate in the biosynthesis of cholesterol (C432501). Cholesterol is a major component of all biological membranes; ~25% of total brain lipid is Cholesterol. Zymosterol was also found to be located in the plasma membrane of cultured human fibroblasts via labeling studies.

Zymosterol-d5 is the deuterated form of zymosterol. Zymosterol is a precursor of cholesterol and the synthesis events occur in rough endoplasmic reticulum.

Zymosterol is a substrate for 24-dehydrocholesterol reductase. It acts as a methyl acceptor and exists as fatty acid ester aerobically-grown yeast cells.