1245699-47-1

The actions of many clinical prostaglandins, including those used for estrous synchronization and for reduction of intraocular pressure, are mediated through the FP receptor. CAY10509 is an analog of PGF_2α containing a thio-fluorobenzene substituent in the lower side chain. CAY10509 has an IC₅₀ of about 30 nM when tested for binding to the recombinant human FP receptor.

CAY10509 is a PGF2α analog and an inhibitor of the FP receptor with an IC50 of 30 nM. CAY10509 is promising for studying physiological regulatory mechanisms related to prostaglandins[1].

FP: 30 nM (IC₅₀)

[1] Negishi M, et al. Prostanoid receptors and their biological actions. Prog Lipid Res. 1993;32(4):417-34. DOI:10.1016/0163-7827(93)90017-q