ChemicalBook CAS DataBase List 1243245-18-2

1243245-18-2

Name	GNF-6231
CAS	1243245-18-2
Molecular Formula	C24H25FN6O2
Molecular Weight	448.49
MOL File	1243245-18-2.mol

Chemical Properties

Melting point	>174°C (dec.)
Boiling point	746.0±60.0 °C(Predicted)
density	1.306±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
form	Solid
pka	12.60±0.70(Predicted)
color	Pale Brown to Light Brown

Hazard Information

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Shanghai XingMo Biotechnology Co., Ltd.

Telephone+86 13524779951; 13524779951

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Shanghai YuanYe Biotechnology Co., Ltd.

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Amadis Chemical Company Limited

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Guangzhou Tomums Life Science Co., Ltd.

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Shanghai Zeye Biotechnology Co., Ltd.

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Shanghai hongqu biomedical technology co. LTD

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Energy Chemical

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Jinan Jiuli Biotechnology Co. , Ltd.

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Hubei Kele Fine Chemical Co., Ltd

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ChemeGen

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Kaifeng Mingren Pharmaceutical Co.,LTD

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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Jieshikai Biotechnology Co. , Ltd.

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https://hanhongsci.com/

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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RD International Technology Co., Limited

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Olix ( Hubei) Pharmaceutical Technology Co., Ltd

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Animal Model:	C57Bl/6 mice model of myocardial infarction^[1]
Dosage:	5 mg/kg
Administration:	Intravenous injection (i.v.); Starting from 6 hours after myocardial infarction surgery to the sixth day after infarction, once every 24 hours
Result:	Reduced nuclear and cytoplasmic β-catenin levels. Reduced adverse cardiac remodeling and reduced myocardial infarction area in mice (9.07%). Enhanced the overall heart repair and recovery after left ventricular infarction.

Animal Model:	Mouse MMTV-WNT1 xenograft tumor model^[2]
Dosage:	0.3 mg/kg,1.0 mg/kg, 3 mg/kg
Administration:	Oral gavage; Once daily for 2 weeks
Result:	At a single dose of 3 mg/kg, reduced the level of Wnt target gene Axin2 mRNA. Promoted tumor regression in mice in a dose-dependent manner.

1243245-18-2

Chemical Properties

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in vivo

storage

Spectrum Detail

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