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Methoxetamine (free base: M226300) is a chemical of the arylcyclohexylamine class. Methoxetamine is considered an analog of Ketamine (K165300) that also contains structural features of eticyclidine and 3-MeO-PCP, and is thought to be psychoactive. Methoxetamine is a product of rational drug design: its N-ethyl group was chosen to increase potency, lessening the risk of interstitial cystitis that can result from the accumulation of Ketamine-like metabolites in the urinary bladder.