ChemicalBook CAS DataBase List 1237744-13-6

1237744-13-6

Name	QNZ-46
CAS	1237744-13-6
EINECS(EC#)	604-604-1
Molecular Formula	C24H17N3O6
MDL Number	MFCD22666391
Molecular Weight	443.41
MOL File	1237744-13-6.mol

Chemical Properties

Melting point	>260 °C
Boiling point	705.8±70.0 °C(Predicted)
density	1.37±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: soluble5mg/mL (warmed; clear solution)
form	Yellow powder
pka	4.28±0.10(Predicted)
color	white to beige
InChI	InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
InChIKey	GNLVJIICVWDSNI-LFYBBSHMSA-N
SMILES	C(O)(=O)C1=CC=C(N2C(=O)C3=C(N=C2/C=C/C2=CC=CC([N+]([O-])=O)=C2)C=CC(OC)=C3)C=C1

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazard Codes	Xn
Risk Statements	22 less more
WGK Germany	3
Storage Class	11 - Combustible Solids

Hazard Information

Uses

QZN-46 is a known antagonist, or non-selective inhibitor, for NDMA-selective glutamate receptors.

Biological Activity

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μMrespectively. QNZ46 does not compete for binding of glutamate or glycinebut QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

in vivo

Ischemic stroke model: QNZ46 (20 mg/kg; i.p.; single administration) significantly reduces brain lesion volume and improved neurological function in transient middle cerebral artery occlusion (tMCAO) mice^[2].
EAE model: QNZ46 (2 mg/kg+1 mg/kg CP465022; i.p.; once a day for 28 days) significantly reduces clinical scores in experimental autoimmune encephalomyelitis (EAE) mice and protected small-diameter myelinated axons in the spinal cord^[3].

Animal Model:	C57BL/6 mice (male, 25-30 g, 8-12 weeks) + transient middle cerebral artery occlusion (tMCAO)^[2]
Dosage:	20 mg/kg (50% DMSO/β-cyclodextrin)
Administration:	Single i.p. injection 120 min prior to ischemia
Result:	Reduced infarct volume by 68%, preserved myelinated axons in the external capsule, and improved neurological performance.

Animal Model:	Animal Model: . C57BL/6 mice (female, 20-22 g, 8-12 weeks) + experimental autoimmune encephalomyelitis (EAE)^[3]
Dosage:	2 mg/kg QNZ46 + 1 mg/kg CP465022 (0.5% methyl cellulose)
Administration:	Daily i.p. injections from day 0 to day 28 post-immunization
Result:	Combined QNZ46/CP465022 treatment reduced clinical severity and preserved small-diameter myelinated axons in spinal cord.

IC 50

NMDA Receptor

storage

room temperature

Spectrum Detail

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