1225038-92-5

SelSA is a selective, orally active inhibitor for histone deacetylase 6 (HDAC6) with IC50 of 56.9 nM. SelSA inhibits the phosphorylation of ERK1/2. SelSA inhibits the proliferation of breast cancer cells and hepatocellular carcinoma cells with IC50 of 0.58-2.6 μM, inhibits cell migration and invasion of Huh7, and induces apoptosis. SelSA exhibits antitumor activity in mouse model[1][2].

HDAC6: 0.0569 μM (IC₅₀); HDAC1: 6.41 μM (IC₅₀); HDAC8: 7.32 μM (IC₅₀)

[1] Yang Z, et al. Histone Deacetylase 6 Inhibitor 5-Phenylcarbamoylpentyl Selenocyanide (SelSA) Suppresses Hepatocellular Carcinoma by Downregulating Phosphorylation of the Extracellular Signal-Regulated Kinase 1/2 Pathway[J]. ACS Pharmacology & Translational Science, 2024.
[2] Tang C, et al. A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy[J]. Journal of Materials Chemistry B, 2019, 7(22): 3528-3536.