1220039-64-4

As a mono-substituted pyridazine derivative, 4-Bromo-pyridazine hydrobromide can be used in the preparation of γ-secretase modulators.

4-Bromopyridazine is synthesized from 3,6-dichloropyridazine in four steps. 1) 3,6-Dichloropyridazine reacts with chlorine at 100°C to give 3,4,6-trichloropyridazine. 2) 3,4,6-Trichloropyridazine is refluxed with 15% NaOH solution. After acidification and