Description
Withangulatin A is a natural potent antitumor agent, targeting sarco/endoplasmic reticulum calcium-ATPase (SERCA).
Uses
Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function[1].
Definition
ChEBI: Withangulatin A is a withanolide.
References
[1] Lijuan Sun, et al. Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. J Cell Biochem. 2010 Feb 15;109(3):532-41. DOI:
10.1002/jcb.22430
