119478-55-6

Crystalline Solid

Danofloxacin is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM

Fluorinated quinolone antibacterial

ChEBI: Danofloxacin mesylate is a member of quinolines.

Danofloxacin mesylate injection is indicated for the treatment of Bovine Respiratory Disease (BRD) associated with Mannheimia (Pasturella) hemolytica and P. multocida in cattle (not dairy or veal). Because of the drug’s spectrum of activity, it may also be of benefit in the treatment of infections caused by Histophilus somni (Haemophilus somnus) or M. bovis, but the drug is not labeled (at the time of writing) for treating these pathogens. In other countries, danofloxacin may be labeled for use in swine and chickens (non-laying), but in the USA it is illegal to use the drug in an extralabel manner in food-producing species.
Danofloxacin may be of benefit in treating susceptible infections in adult horses, camelids and other non-food producing species.

[1] A.C. COOPER. In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance[J]. Research in veterinary science, 1993, 54 3: Pages 329-334. DOI: 10.1016/0034-5288(93)90130-8
[2] PAUL R. MCGUIRK. Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine[J]. Journal of Medicinal Chemistry, 1992, 35 4: 611-620. DOI: 10.1021/jm00082a001
[3] MIN YAO. The regulation effects of danofloxacin on pig immune stress induced by LPS[J]. Research in veterinary science, 2017, 110: Pages 65-71. DOI: 10.1016/j.rvsc.2016.11.005